Production of hydroxyl radical by human alveolar macrophages
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چکیده
منابع مشابه
Evidence for hydroxyl radical production by human neutrophils.
The possibility that neutrophils produce the hydroxyl radical (OH-) was studied by examining the ability of these cells to support the release of ethylene from methional, a reaction in which it has been shown that OH-, but not O2- or H2O2, may serve as the oxidizing agent. When neutrophils were exposed to opsonized zymosan in the presence of 0.35 mM methional, ethylene was released in quantitie...
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The role of alveolar macrophages in the production of granulocyte/ macrophage colony-stimulating factor(s) by the rat lung was investigated. Lavaged lungs, when incubated at proper weight per volume of culture medium, produced the same amount of colony-stimulating factor as unlavaged ones. Both lavaged and unlavaged lungs produced similar types of colony-stimulating factor (s). Prolonged i...
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Acton, Jean D. (Bowman Gray School of Medicine, Winston-Salem, N.C.), and Quentin N. Myrvik. Production of interferon by alveolar macrophages. J. Bacteriol. 91:2300-2304. 1966.-Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable at pH 4, is not sedimented at ...
متن کاملThe production of hydroxyl radical by tallysomycin and copper(II).
Tallysomycin is an antitumor antibiotic that is structurally related to bleomycin. The mechanism of action of tallysomycin appears to be similar to that of bleomycin. Bleomycin induces strand scission of purified isolated DNA [ l--5]. Bleomycin has also been shown to produce breakage of intracellular DNA [5,6]. Iron(H) appears to be associated with the mechanism of action of bleomycin. The foll...
متن کاملThe production of hydroxyl radical by bleomycin and iron (ii).
Bleomycin 1s a glycopeptidlc antlblotlc used for the treatment of cancer [l] . In vitro, a major effect of bleomycm 1s the mtroduction of strand breaks into DNA [2,3]. Efficient breakage of DNA by bleomycm requues the presence of reducing agents, such as 2-mercaptoethanol, dltiothreitol, ascorbate, or hydrogen peroxlde [3,4]. Although reducing agents alone are injurious to DNA [5,6], the combin...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1979
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.26.3.1088-1092.1979